Or maybe with something else? For example, with the rehabilitation of scars using medical silicone?
I invite you to read an interesting study that shows and explains how silicone works in contact with a scar and what results can be expected when using modern silicone dressings, e.g. Codosil™ ADHESIVE.
Scars can be atrophic, hypertrophic, i.e. those that grow only within the scar, or keloid, i.e. those that are characterized by excessive production of collagen, so they uncontrollably grow beyond the edges of the scar, as well as those that heal correctly.
"Topical silicone gel has shown promise in the treatment of hypertrophic and keloid scars. However, its mechanism of action remains undetermined.” The aim of the authors of this article* was to determine whether the presence of silicone has an impact on the production of the fibroblast growth factor produced by keratinocytes: bFGF - cytokines with properties enhancing the maturation of fibroblasts and the production of collagen For this reason, a serum-depleted fibroblast culture was established from normal, keloid and fetal skin which heals without scarring. The above culture was then treated with silicone gel. Subsequently, “serial cell counts were performed, and supernatants were collected for bFGF quantification by enzyme-linked immunosorbent assay at 4, 24, 72, and 120 hours."
“The growth curves were similar to each other and no statistically significant differences in population doubling time were observed between the silicone gel treated and non-silicone gel treated samples. Statistically significant differences in bFGF levels between normal gel treated and untreated fibroblasts were observed at 24, 72 and 120 hours after initiation of cell growth. Differences in bFGF levels in silicone gel treated and non-silicone gel treated fetal fibroblasts were observed after 72 and 120 hours.”*
“These results suggest that silicone gel is responsible for increased bFGF levels in normal and fetal dermal fibroblasts. We postulate that silicone gel treats and prevents hypertrophic scar tissue, which contains histologically normal fibroblasts, by modulating expression of growth factors such as bFGF. Our data support the hypothesis that substances that favorably influence wound healing do so by correcting a deficiency or overabundance of the growth factors that orchestrate the tissue repair process.”*
As the above study has shown that the use of silicone material in the rehabilitation of scars and keloids is effective and safe, it can be assumed that also the Codosil™ ADHESIVE silicone dressing is safe and effective.
Bibliography
The effect of silicone gel on basic fibroblast growth factor levels in fibroblast cell culture
*Hanasono, M. M., Lum, J., Carroll, L. A., Mikulec, A. A., & Koch, R. J. (2004). The effect of silicone gel on basic fibroblast growth factor levels in fibroblast cell culture. Archives of facial plastic surgery, 6(2), 88-93.
